R5; Background A model of simulated Alzheimer's disease (AD) induced by aggregated amyloid protein (Aβ1-40) was built in Wister rats to observe the behavioral and pathological changes of Aβ1-40 and the effect of hypodermic insulin injected on the function of study and memory and the expression of Aβ1-40 from the CA1 area of the hippocampus.Methods Experimental groups were as follows: contrast, simulated AD model, contrast of Nacl, and insulin treated. The simulated AD modet was built by microinjection of aggregated Aβ1-40 at the CA1 area of the hippocampus, and was hypodermically injected with 0.9% NaCI (1 ml/kg) and insulin (0.1 U/kg) separately the next day. Two weeks after the modeling, the four groups were tested with water maze about the study and memory function of rats. Three weeks after the injection, the expression of Aβ1-40 at the CA1 area of the hippocampus was examined by pathological tests (HE,Congo red) and immunohistochemical methods.Results The study and memory abilities of rats were ameliorat

Chinese medical journal

insulin; hippocampal area; Aβ1-40; Alzheimer's disease