Crohn's disease (CD) is characterized by transmural inflammation that is most frequently located in the region of the terminal ileum. Although the physiopathological mechanisms of the disease are not yet well defined, the unregulated immune response is associated with high production of reactive oxygen species (ROS). These elements are associated with complex systems known as antioxidant defenses, whose function is ROS regulation, thereby preventing the harmful effects of these elements. However, the presence of an imbalance between ROS production and ROS elimination by antioxidants has been widely described and leads to oxidative stress. In this article, we describe the most significant findings on oxidative stress in the intestinal mucosa and peripheral blood.

Gastroenterología y hepatología

Intestinal Mucosa - metabolism; Reactive Oxygen Species - metabolism; Oxidative Stress; Humans; NADPH Oxidases - metabolism; Crohn Disease - metabolism; Leukotriene B4 - biosynthesis; Hydrogen Peroxide - blood; Intestinal Mucosa - immunology; Anti-Inflammatory Agents - therapeutic use; Neutrophils - metabolism; Lymphocytes - metabolism; Catalase - immunology; Catalase - physiology; Reactive Nitrogen Species - metabolism; Inflammation; Crohn Disease - immunology; Autoantibodies - immunology; Crohn Disease - pathology; Crohn Disease - blood; Crohn Disease - drug therapy; PPAR gamma - agonists; Probiotics - therapeutic use; Intestinal Mucosa - pathology; Nitric Oxide Synthase Type II - metabolism; Index Medicus; Enfermedad de Crohn; Catalasa; Oxidative stress; Crohn's disease; Catalase; Estrés oxidativo

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