cam a22 4 4500 57691987X CHVBK 20201202101006.0 191204s2019 sz a m 00 0deng d urn:nbn:ch:bel-1776392 urn (SNL)991018015425803976 (IDSBB)007130829 (SNL)991018100750703976 (NEBIS)011520359 (Sz)991018015425803976 (Sz)991018100750703976 Sz ger rda 610 23sdnb 616 15 Berg Machteld <<van den>> 1989- (DE-588)1200893123 Verfasser aut Ethical implications of malaria vaccine development submitted by Machteld van den Berg Zurich 2019 183 Seiten Illustrationen 30 cm Enthält verschiedene Sonderdrucke Dissertation Universität Zürich, 2019 Literaturverzeichnis PDF Clinical trials conducted in low-resource settings have unique challenges associated with their conduct. This is mainly attributed to the power and resource discrepancy between actors in the clinical trial. This thesis provides an in-depth look at clinical trials in low-resource settings and the effects of the resource discrepancy on the actors. It aims to answer what the ethical challenges are when conducting research in low-resource settings and the subsequent implications for research design. It focuses on capturing both the experience of caregivers of pediatric participants and the frontline researchers in a malaria vaccine clinical trial. Through exploring these two stories and bridging the relational with the formal, it provides a novel approach to address the challenges with research in low-resource settings. This approach employs the lens of complexity theory to evaluate the outcome of two systems, a human community and a clinical trial, merging. I will begin by outlining a general introduction of clinical trials in low-resource settings and the case study of a pediatric malaria vaccine clinical trial, here I detail the need to generate a vaccine against malaria and outline why such research should take place. This situates the reasons for the study and provides familiarity with the contextual reality. Then I will move into detailing the caregiver experiences, researcher experiences, and the application of complexity theory to bridge together the different experiences. This thesis is a result of qualitative data gathered from 78 interviews with caregivers of pediatric participants and 11 interviews with researchers involved on the frontline of a pediatric malaria vaccine clinical trial. The final part of the thesis is a theoretical reflection that explores the realities faced by researchers and argues for an approach that embraces the non-linearity of research taking place in human communities. Here I identify the challenges associated with choice and structural inequity, the conflict between beneficence and autonomy, and being a frontline researcher in low-resource settings. Hochschulschrift (DE-588)4113937-9 gnd-content Hochschulschrift (DE-588)4113937-9 gnd Hochschulschrift gnd-content sb 2019/24 610 zh snl-sb xehelv xediss 2020 610 snl ehelv Universität Zürich (DE-588)36190-2 Grad-verleihende Institution dgg SNL NB001 NB999 - chb99 - IDSBB A322 A322 FH - Holding für Migration per Programm erstellt - https://opac.admin.ch/toc/toc1902094322.pdf Inhaltsverzeichnis BK020300 XK020000 XK020000 zbzdis201911e kohl zbzswk201911d idszbz Z2 ZH idszbz Z1 Dissertation Faculty of Medicine idsuzh U Dissertation University of Zurich. Institute of Biomedical Ethics and History of Medicine idsuzh U UNI-ZH nebis E2 SNL NB001 NB001 Nbq 123452 NB10010 SNL 100 1- Berg Machteld <<van den>> 1989- (DE-588)1200893123 Verfasser aut SNL 856 41 https://opac.admin.ch/toc/toc1902094322.pdf Inhaltsverzeichnis IDSBB 100 1- Van den Berg Machteld Verfasser aut IDSBB 700 1- Biller-Andorno Nikola 1971- (DE-588)115724028 Akademischer Betreuer dgs IDSBB 700 1- Tanner Marcel 1952- (DE-588)171409671 Akademischer Betreuer dgs IDSBB 700 1- Merten Sonja Akademischer Betreuer dgs SNL 710 2- Universität Zürich (DE-588)36190-2 Grad-verleihende Institution dgg SNL 100 1- Van den Berg Machteld Verfasser aut SNL 856 40 https://doi.org/10.5167/uzh-176779 SNL 856 4- https://nbn-resolving.org/urn:nbn:ch:bel-1776392 SNL 856 42 http://www.e-helvetica.nb.admin.ch/directAccess?callnumber=bel-1776392 NEBIS 100 1- Berg Machteld van den 1989- (DE-588)1200893123 Verfasser aut NEBIS 700 1- Biller-Andorno Nikola 1971- (DE-588)115724028 Akademischer Betreuer dgs NEBIS 700 1- Tanner Marcel 1952- (DE-588)171409671 Akademischer Betreuer dgs NEBIS 700 1- Merten Sonja Akademischer Betreuer dgs NEBIS ZAD50 https://opac.nebis.ch/objects/pdf03/z01_011520359_01.pdf Titelblatt und Inhaltsverzeichnis VIEW pdf